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KMID : 0380620170490060649
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Korean Journal of Food Science and Technology
2017 Volume.49 No. 6 p.649 ~ p.658
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Ethyl acetate fraction from Pteridium aquilinum ameliorates cognitive impairment in high-fat diet-induced diabetic mice
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Kwon Bong-Seok
Guo Tian Jiao
Park Seon-Kyeong
Kim Jong-Min
Kang Jin-Yong
Park Sang-Hyun
Kang Jeong-Eun
Lee Chang-Jun
Lee Uk
Heo Ho-Jin
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Abstract
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The potential of the ethyl acetate fraction from Pteridium aquilinum (EFPA) to improve the cognitive function in high-fat diet (HFD)-induced diabetic mice was investigated. EFPA-treatment resulted in a significant improvement in the spatial, learning, and memory abilities compared to the HFD group in behavioral tests, including the Y-maze, passive avoidance, and Morris water maze. The diabetic symptoms of the EFPA-treated groups, such as fasting glucose and glucose tolerance, were alleviated. The administration of EFPA reduced the acetylcholinesterase (AChE) activity and malondialdehyde (MDA) content in mice brains, but increased the acetylcholine (ACh) and superoxide dismutase (SOD) levels. Finally, kaempferol-3-o-glucoside, a major physiological component of EFPA, was identified by using high-performance liquid chromatography coupled with a hybrid triple quadrupole-linear ion trap mass spectrometer (QTRAP LC-MS/MS).
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KEYWORD
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cognitive function, diabetes, high-fat diet, Pteridium aquilinum
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